| Position |
Associate Professor
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| Affiliation |
National Institute of Biomedical Genomics
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| Location |
nan
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| Current Role |
Scientist;Teaching
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| Area of Research |
Major challenges in breast cancer are understanding the reasons for tumor recurrence and having therapeutics to treat resistant tumors. Our laboratory employs molecular, cellular and genomic technologies to identify novel long non-coding RNAs, study the contribution of serum derived exosomes, and an epigenetic regulator, Jumonji domain containing protein 6 (JMJD6) to aggressive behavior in tumors. In the long run, we hope to develop molecular probes/tests for improved prediction of cancer progression and disease recurrence by integrating our various approaches.
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| UG |
Chemistry - 1990- University of Pune
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| PG |
Biochemistry - 1992 - University of Pune
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| PhD |
Molecular Reproduction Development and Genetics- 1999 Indian Institute of Science, Bengaluru
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| Awards |
1. Technology Transfer Award 2002 Center for Cancer Research, NIH
2. Outstanding postdoctoral researcher 2003 and 2004 National Cancer Institute, NIH
3. Selected for the Scientific Bilateral Exchange Program with overseas Academies/Organizations 2016, Czech Republic, Long term Fellowship (NOT availed)
4. Selected for Short-term Fellowship of 3 months (Jun 2017-Aug 2017) at a foreign Institute (University of Chicago) under the Human Resource Development Scheme by Department of Health Research (F.V.25011/533-HRD-HRD/2016-HR)
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| Significant Contribution |
1. JMJD6 (Jumonji domain containing protein 6) induces the lincRNA HOTAIR by interacting with its basal promoter. Simultaneous high expression of both these RNAs signals poor survival in breast cancer patients
2. JMJD6 and EZH2 both increase cell proliferation and regulate E2F and DREAM targets, albeit by different mechanisms. Blocking both these proteins will be necessary to prevent cancer growth and of greater clinical benefit.
3. JMJD6 binds HOTAIR RNA physically and may recruit it to target sites for gene regulation.
PATENT
US patent.: US2012/0100144 “A biomarker and treatment for cancerâ€
Inventors: Kartiki V DESAI; Edison LIU; Lance D. MILLER
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| Bio |
Dr. Kartiki V. Desai was a post-doctoral fellow at the National Cancer Institute (NIH) where she analyzed and compared gene expression profiles of several rodent models of human breast and prostate cancer (1999-2005). As a Research Scientist at the Genome Institute of Singapore, she identified novel therapeutic targets in breast cancer by integrating bioinformatics tools with clinical data, followed by High-Content Screening and deep functional validation of each candidate that associated with poor disease outcome (2006-2011). She served on the HUGO council (2011-2014) and is a Review Editor for Frontiers in Cancer Genetics, Editorial Board member for Journal of Genetics. She is a member of Technical Expert Committee on Genomic Technologies, DBT and STAG Knowledge Generation and Discovery Research, New tools and technologies. She also is a member of the Governing Board of International Association of Breast Cancer Research (IABCR).
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| Primary Role |
Research; Teaching
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| Leadership |
Sr. No Committee Role
1 Committee for Protection of Research Risks to Humans Convener
2 Internal Complaints Committee Chair
3 Safety and Security Committee Chair
4 Various Ph.D and project linked staff interview committees Chair/Member
5 Standing Committee for shortlisting and recommending fellows seeking sponsorship of NIBMG for application to Fellowships of Government of India Chair
5 Institute Hindi Committee Member
6. Hostel Committee Warden
7 Committee to review all projects prior to submission to a funding agency Member
8 Committee for drafting rules for Utilization of Institute Development Fund Member
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| Twitter |
nan
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| Contact |
kd1@nibmg.ac.in
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