| Position |
Associate Professor
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| Affiliation |
Amity Institute of Molecular Medicine and Stem Cell Research
|
| Location |
nan
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| Current Role |
Scientist
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| Area of Research |
My current research interest is to explore novel targets, genes, approaches for cancer
diagnosis, prognosis and therapy. My research team is specifically focused on how epigenetic pathways such as histone methylation/acetylation, chromatin regulatory proteins and genetic events such as gene amplification contribute to tumorigenesis and chemo/radio resistance in ovarian and breast cancers. We aim to translate our findings into developing better therapeutic strategies using novel combination and new epigenetic durgs to treat this life-threatening disease.
|
| UG |
Microbiology-2002-Devi Ahilya University/Holkar Science College
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| PG |
Industrial Microbiology-2004-Devi Ahilya University/School of Life Sciences
|
| PhD |
2012-University of Cologne, Germany
|
| Awards |
Ramalingaswami Re-entry fellowship 2018 – 2023
Funded by Department of Biotechnology (DBT), India
• Early Career Research grant 2018 – 2021
Funded by Department of Science & Technology (DST), India
• Bio-Care Research grant 2017 – 2021
Funded by Department of Biotechnology (DBT), India
• Dr. DS Kothari Postdoctoral Fellowship 2017
Funded by University Grants Commission (UGC), India (not availed)
• Postdoctoral funding 2013 – 2016
Funded by Cancer Research UK (CRUK)
• PhD funding 2008 – 2012
Funded by German Research Foundation (DFG)
|
| Significant Contribution |
As a research team, we have identified two genes CDC25C and UBE2Q1 as potential prognostic biomarkers in breast and ovarian cancer. Current studies are ongoing to identify role of histone demethylases and histone acetyltransferase in cisplatin resistance and cancer development.
KEY PUBLICATIONS (TOTAL PUBLICATIONS: 11)
Topno R$; Singh I$; Kumar M*; Agarwal P* (2021) Integrated bioinformatic analysis
identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer;
BMC Cancer Mar 4;21(1):220. (*corresponding Author) (IF- 4.4)
Topno R$; Nazam N$; Kumari P, Kumar M*; Agarwal P* (2021); Integrative genome wide
analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive
marker for chemoresistance in breast cancer; Cancer Biomarkers July 9, 1-14
(*corresponding Author) (IF- 4.38)
Agarwal P, and Jackson SP. (2016) G9a inhibition potentiates the anti-tumour activity of
DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.Cancer Letters 16;380(2):467-475 (IF – 7.36)
Agarwal P, Schulz JN, Blumbach K, Heinegård D, Paulsson M, Mauch C, Eming C, Eckes
B, Krieg T. (2013) Enhanced expression of cartilage oligomeric matrix protein is a common
feature in fibrotic skin pathologies Matrix Biology 32:325–331 (IF – 8.57)
Agarwal P*, Zwolanek D*, Keene DR, Schulz JN, Blumbach K, Heinegård D, Zaucke F,
Paulsson M, Krieg T, Koch M, Eckes B. (2012) Collagen XII and XIV - new partners of
cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure, Journal of
Biological Chemistry 287(27): 22549-59 (IF – 5.15)
|
| Bio |
After completing my PhD degree from University of Cologne, Germany, I pursued my postdoctoral research at Gurdon Institute, University of Cambridge, UK, where I investigated how small molecule inhibitors of epigenetic pathways could be targeted for cancer therapy. I showed methyltransferase G9a inhibitors as cancer therapeutic agents, which can act by potentiating the anti-tumor activity of DNA double strand break-inducing agents. During my international journey of nearly 10 years, I actively participated and delivered talks at various international conferences/meetings including EMBO meeting. I initiated collaboration with Scientists from USA, Sweden, Germany and UK to build long-term collaborative network. At Amity University, I am now supervising 4 students as main guide and 2 as co-guide. Two of my students have received fellowships (DST-WOSA and ICMR-RA) under my mentorship. One of my student is MMBS/MD pursuing his PhD degree under me.
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| Primary Role |
Research;Teaching
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| Leadership |
Faculty in charge - Alumni, Faculty in charge - Training/Dissertation, Program Leader, Member of PROAC, Placement Cell, Student, Heads of Examination Committee and Student Assessment Committee
|
| Twitter |
nan
|
| Contact |
pagarwal6@amity.edu
|
