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SUTAPA MUKHERJEE

SUTAPA MUKHERJEE Image

Position SENIOR SCIENTIFIC OFFICER
Affiliation DEPT. of ENVIRONMENTAL CARCINOGENESIS & TOXICOLOGY, CHITTARANJAN NATIONAL CANCER INSTITUTE, KOLKATA, INDIA
Location nan
Current Role Scientist
Area of Research Environmental toxicants and their impact on cancer. Underlying molecular mechanisms of cancer chemo / radioresistance with particular emphasis on serine / threonine kinase mediated signaling. Role of stemness factors in regulation of serine/threonine kinase signaling and their implication on cell division.
UG Life Science (Zoology) -1996-VISVA BHARATI UNIVERSITY
PG Life Science (Zoology) -1998-VISVA BHARATI UNIVERSITY
PhD 2005-JADAVPUR UNIVERSITY
Awards Recipient of Young Scientist Award in the 92nd Indian Science Congress held at Ahmedabad January 3-7, 2005. Awarded “Professional Diploma in clinical Research (PDCR)” and received a Certificate of Merit by Catalyst Clinical Services; February, 15 2010.
Significant Contribution Reviewer of peer reviewed journals: 1. Human & Experimental Toxicology, SAGE Publications 2. Gene Reports, ELSEVIER Publication 3. Oral Science International, Wiley Online Library 4. Cancer Management and Research, Dovepress Reviewer of many thesis of 1. Jadavpur University 2. Amity University Other Professional Engagements: • Life Member, Indian Association for Cancer Research (IACR) • Life Member, Society for Biological Chemists (SBC) • Life Member, Environmental Mutagen Society of India (EMSI) • Executive Committee Member, ALL INDIA CONGRESS OF CYTOLOGY & GENETICS (ESTD. - 1971). Contribution to Academic Administration of the Institute by acting as Academic Coordinator since February, 2013.
Bio CURRICULUM VITAE Name: Dr. Sutapa Mukherjee https://orcid.org/0000-0002-4411-7257 Designation: Senior Scientific Officer (SSO-I grade) Official Address: Dept of Environmental Carcinogenesis & Toxicology Chittaranjan National Cancer Institute 37, S.P. Mukherjee Road Kolkata - 700 026. Tel No: 91-33-2476-5101 (Extn 317, 320) Mobile Number: 98304 16205 E mail: sutapa_c_in@yahoo.com, sutapamukherjee@cnci.ac.in Academic Qualifications: Degree Board / University Year Subject B.Sc Visva Bharati 1996 Life Science (Zoology) M.Sc Visva Bharati 1998 Life Science (Zoology) PhD Jadavpur 2005 Science Thesis Title: Modulation of carcinogen induced DNA damage and induction of apoptosis by natural compounds in cell culture system Positions Held at CNCI, Kolkata: 1. Senior Scientific Officer-II July, 2009 2. Senior Scientific Officer (SSO-I Grade) March, 2015 - till date Major Research Interest Understanding the underlying molecular mechanisms of chemo and radio resistance involving serine threonine kinases. Involvement of PI3K/Akt/IAP signaling axis in acquirement of chemoresistance. Telomerase and telomere interactions and chromosomal instability in cancer. Environmental toxicants and their impact on cancer. Future Research Programme/ Plan (with details): Understanding the molecular mechanism underlying chemoresistance at protein and genetic levels involving serine threonine kinases and Inhibitor of Apoptosis Proteins (IAPs). Identification of the status of Aurora A/B and IAPs in chemo resistant scenario of different cancers. Epigenetic changes of different target proteins of serine threonine kinases which are key molecular factors for chemoresistance. Genetic transfection assay and transcriptome profiling of serine threonine kinases particularly Aurora kinase A/B and IAPs in different types of cancer. Interactome analysis of protein-protein and protein-DNA complexes, which are imparting the role in the development of acquired chemoresistance. Telomere-telomerase interactions and their targets in cancer. Publication Lists: a. Papers Published: 39 1. Roy Madhumita, Chakraborty Sutapa, Siddiqi Maqsood and Bhattacharya Rathin K (2002). Induction of apoptosis in tumor cells by natural phenolic compounds, Asian Pacific J of Cancer Prevention, Vol.3, No. 1, 61-67. 2. Chakraborty Sutapa, Roy Madhumita, Hazra Banasri and Bhattacharya RK (2002). Induction of apoptosis in human cancer cell lines by diospyrin, a plant derived bisnaphthoquinonoid and its synthetic derivatives. Cancer Letter, 188, 85-93. 3. Roy Madhumita, Chakraborty Sutapa, Dona Sinha, RK Bhattacharya and M Siddiqi (2003). Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate, a green tea polyphenol. Mutation Research, 523-524, 33-41. 4. Chakraborty Sutapa, Roy Madhumita and Bhattacharya RK (2004). Prevention and Repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. J Environmental Pathology, Toxicology and Oncology, 23(3), 215-226. 5. Chakraborty Sutapa, Roy Madhumita, Taraphdar Amit K and Bhattacharya RK (2004). Cytotoxic effect of root extract of Tiliacora racemosa and Semecarpus anacardium nut in human tumor cells. Phytotherapy Res, 18(8), 595-600. 6. Halder Maheswar, Mukherjee Sutapa, Roy Madhumita and Ray Jay Gopal (2005). Evaluation of DNA damage in whole blood of patients with oral precancers and oral squamous carcinoma by comet assay, The J Indian Dental Association, West Bengal State Branch, Vol 21, No. 3, 32-40. 7. Chakraborty Sutapa, Ghosh Utpal, Bhattacharya N P, Bhattacharya R K and Roy Madhumita (2006). Inhibition of telomerase activity and induction of apoptosis by curcumin in K562 cells. Mutation Research 596, 81-90. 8. Chakraborty (Mukherjee) Sutapa, Kundu Trina, Dey Subhabrata, Bhattacharya Rathin K, Siddiqi Maqsood and Roy Madhumita (2006). Tea induced apoptosis in human leukemia K562 cells as assessed by comet formation. Asian Pacific J of Cancer Prevention, 7, 201-207. 9. Mukherjee (Chakraborty) Sutapa, Ghosh Utpal, Bhattacharyya NP, Battacharya Rathin K, Dey Subhabrata and Roy Madhumita (2007). Curcumin induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Molecular and Cellular Biochemistry, 297, 31-39. 10. Mukherjee Sutapa, Roy Madhumita, Dey Subhabrata and Bhattacharya Rathin K (2007). A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb Curcuma longa Linn. J of Clinical Biochemistry and Nutrition, 41, 32-42. 11. Roy Madhumita, Sinha Dona, Mukherjee Sutapa, Paul Susmita, Bhattacharya Rathin K (2008). Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells. Indian Journal of Experimental Biology, 46: 690-697. 12. Mukherjee Sutapa, Dey Subhabrata, Bhattacharya Rathin K, Roy Madhumita (2009). Isothicyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. Molecular and Cellular Biochemistry; 330:9-22. 13. Mukherjee Sutapa, Bhattacharya Rathin K, Roy Madhumita (2009). Targeting PKC and telomerase by PEITC sensitizes PC-3 cells towards chemotherapeutic drug induced apoptosis. J Environmental Pathology Toxicology & Oncology; 28(4): 269-282. 14. Sinha Dona, Mukherjee Sutapa, Roy Soumi, Bhattacharya Rathin K, Roy Madhumita (2009). Modulation of arsenic induced genotoxicity by curcumin in human lymphocytes. J Env Chem Ecotoxicol, Vol. 1(1) November, pp. 001-011. 15. Biswas Jaydip, Sinha Dona, Mukherjee Sutapa, Roy Soumi, Siddiqi Maqsood and Roy Madhumita (2010). Curcumin protects DNA damage in a chronically arsenic exposed population of West Bengal. Human Experimental Toxicology; 29(6): 513-524. 16. Biswas Jaydip, Roy Soumi, Mukherjee Sutapa, Sinha Dona and Roy Madhumita (2010). Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in swiss albino mice Asian Pacific J Cancer Prevention; 11: 239-249. 17. Roy Madhumita, Sinha Dona, Mukherjee Sutapa and Biswas Jaydip (2011). Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. European J Cancer Prevention; 20(2):123-131; doi: 10.1097/CEJ.0b013e328341017a. 18. Roy Madhumita, Mukherjee Sutapa, Sarkar Ruma and Biswas Jaydip (2011). Curcumin sensitizes the effect of chemotherapeutic drugs via modulation of Protein Kinase C, Telomerase, NFB and Histone Deacetylase in Breast Cancer. Therapeutic Delivery; 2(10):1275-1293. 19. Mukherjee Sutapa, Sarkar Ruma, Biswas Jaydip and Roy Madhumita (2012). Curcumin inhibits histone deacetylase leading to cell cycle arrest and apoptosis via upregulation of p21 in breast cancer cell lines. Int J Green Nanotech; 4:183–197. 20. Roy Madhumita, Mukherjee Sutapa and Biswas Jaydip (2012). Inhibition of an epigenetic modulator, histone deacetylase by PEITC in breast cancer- a detailed mechanistic approach. International Journal of Therapeutic Applications; 5: 1-13. 21. Sarkar Ruma, Mukherjee Sutapa, Biswas Jaydip and Roy Madhumita (2012). Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins. Biochemical and Biophysical Research Communications; 427: 80-85. 22. Sarkar Ruma, Mukherjee Sutapa and Roy Madhumita (2013). Targeting Heat Shock Proteins (HSPs) by PEITC results in cell cycle arrest and apoptosis of human breast cancer cells. Nutrition and Cancer; 65(3):480-493. 23. Roy Madhumita, Mukherjee Sutapa (2014). Reversal of resistance towards cisplatin by curcumin in cervical cancer cells. Asian Pac J Cancer Prevention; 15(3):1403-10. 24. Sarkar Ruma, Mukherjee Apurba, Mukherjee Sutapa, Biswas Raj, Biswas Jaydip and Roy Madhumita (2014). Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of Heat Shock Proteins via HDAC6. J Environ Pathol Toxicol Oncol; 33(3):247-63. 25. Roy Madhumita, Kunnumakkara Ajaikumar, Mukherjee Apurba, Sarkar Ruma, Mukherjee Sutapa and Biswas Jaydip (2015). Repair activity impaired by arsenic: recovery by phytochemicals. Int. J. Curr. Microbiol. App. Sci 4(3): 578-587. 26. Roy Madhumita, Sarkar Ruma, Mukherjee Sutapa, Mukherjee Apurba and Biswas Jaydip (2015). Sulforaphane inhibits metastatic events in breast cancer cells through genetic and epigenetic regulation. J Carcinog Mutagen 2015, 6:4. 27. Roy Madhumita, Sarkar Ruma, Mukherjee Apurba, Mukherjee Sutapa (2015). Inhibition of crosstalk between Bcr-Abl and PKC signaling by PEITC, augments imatinib sensitivity in chronic myelogenous leukemia cells. Chemico Biological Interaction 242: 195-201. 28. Sarkar Ruma, Mukherjee Sutapa, Biswas Jaydip, Roy Madhumita (2016). Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target. Free Radical Research. 50(1):84-100. 29. Roy Madhumita, Sarkar Ruma, Mukherjee Sutapa, Mukherjee Apurba, Biswas Jaydip (2015), Sulforaphane Inhibits Metastatic Events in Breast Cancer Cells through Genetic and Epigenetic Regulation, J Carcinog Mutagen, 6(4):1-8. 30. Mukherjee Apurba, Sarkar Ruma, Mukherjee Sutapa, Biswas Jaydip, Roy Madhumita (2016). Curcumin boosts up the efficacy of Imatinib Mesylate in chronic myelogenic leukemia cell line K-562 by modulation of various markers. Int J Curr Microbiol. App. Sci, 5(12): 240-255. 31. Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip, Roy Madhumita (2017). Imatinib mesylate resistance in chronic myelogenous leukemia cells may be overcome by Indian Spice Curcumin. Int J Med Sci Invative Res; 2(6): 535-543. 32. Mukherjee Apurba, Mukherjee Kalyan Kusum, Mukherjee Sutapa, Roy Madhumita (2018). Curcumin May Enhance the Efficacy of Anti-Leukemia Drugs in Myeloid Leukemia. Int.J.Curr.Microbiol.App.Sci 7(5): 3274-3283. 33. Mukherjee Apurba, Mukherjee Sutapa, Roy Madhumita (2019) Curcumin plays a dual role: in adjuvant therapy and reversal of drug resistance in Acute Myelogenous Leukemia, International Journal of Current Medical and Pharmaceutical Research, 5(2A): 4078-4084. 34. Roy Madhumita, Mukherjee Sutapa (2019). Black tea extract prevents 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by targeting protein tyrosine kinases and associated biological response. Clinical Oncology & Research, 2(1): 2-7, doi:10.31487/j.COR.2019.01.002; ISSN 2613-4942. Available Online at www.sciencerepository.org 35. Biswas Souvick, Mahapatra Elizabeth, Roy Madhumita, Mukherjee Sutapa (2020). PEITC by regulating Aurora Kinase A reverses chemoresistance in breast cancer cells. Indian Journal of Biochemistry and Biophysics (IJBB), 57(2): 167 – 177. 36. Mahapatra Elizabeth, Biswas Souvick, Roy Madhumita, Mukherjee Sutapa (2020). Inflammation: A protagonist in development of carcinogen induced cervical cancer in mice. Indian Journal of Biochemistry and Biophysics (IJBB), 57(2): 158 – 166. 37. Ghosh Archismaan, Mukherjee Apurba, Mukherjee Sutapa, Roy Madhumita (2020). Assessment of Susceptibility towards iAs Induced Carcinogenesis in West Bengal, India. Int. J. Curr. Microbiol. App. Sci, 9(3): 1998-2011. 38. Ghosh Archismaan, Mukherjee Apurba, Mukherjee Sutapa, Roy Madhumita, Datta A (2021). Modulatory role of tea in arsenic induced epigenetic alterations in carcinogenesis. The Nucleus, https://doi.org/10.1007/s13237-020-00346-9. 39. Biswas Souvick, Mahapatra Elizabeth, Ghosh Archismaan, Das Salini, Roy Madhumita, Mukherjee Sutapa (2021). Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells. Asian Pacific Journal of Cancer Prevention: APJCP, 22(3): 957-970. b. Reviews: 8 1. Roy Madhumita, Chakraborty Sutapa, Sinha Dona, Kundu Trina and Bhattacharya RK. Polyphenols and Cancer. Science and Culture, 70 (No. 3-4), 136-141, 2004. 2. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa and Jaydip Biswas (2014). Arsenic: an alarming global concern. Int. J.Curr. Microbiol. App.Sci; 3(10):34-47. 3. Roy Madhumita, Mukherjee Apurba, Sarkar Ruma, Mukherjee Sutapa, Biswas Jaydip (2015). In search of natural remediation for cervical cancer. Anticancer Agents Med Chem, 15(1): 57-65. 4. Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip, Roy Madhumita (2015). Phytochemicals in obesity control. Int.J.Curr.Microbiol.App.Sci (2015) 4(4): 558-567. 5. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip (2016). Phytonutrients from fruits and vegetables in breast cancer control. Indian Perfumer, Vol 60 (3). 6. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip (2017). Nutraceuticals in leukemia. J Ayurvedic and Herbal Medicine, 3(1): 41-47. 7. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip (2017). Phytochemicals as an adjuvant in leukemia therapy. eBook on Leukemia: Causes, Symptoms & Treatment. 8. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip (2017). Drug Resistance in Leukemia: Remediation by Natural Means. Biomed Res J 2017;4(1), 8-27. c. Book Chapters: 6 1. Chakraborty Sutapa, Madhumita Roy and Bhattacharya Rathin K (2006). Tumor cell apoptosis by phytochemicals and herbal extracts: Herbal Drugs, A twenty First Century Perspective Eds. R H Sharma and Rajesh Arora, JAYPEE Brothers, Article 35, pg 342-351. 2. Roy Madhumita, Mukherjee Apurba, Mukherjee Sutapa and Biswas Jaydip (Feb 2014). Phytonutrients from Fruits and Vegetables in Breast Cancer Control. Anticancer properties of fruits and vegetables: A Scientific Review. Publisher: World Scientific Publishing, Singapore, Chapter 3, Page 75-101, edited by Dr. Ajaikumar B. Kunnumakkara. 3. Roy Madhumita, Sarkar Ruma, Mukherjee Apurba, Mukherjee Sutapa, Biswas Jaydip (2018). Phytochemicals as chemosensitizers in breast cancer. Cancer Cell Chemoresistance and Chemosensitization, Chapter 6, pg 129 – 162. World Scientific Publishing, Singapore, edited by Dr. Ajaikumar B. Kunnumakkara, Bordoloi Devivasha, Monisha Javadi. 4. Mukherjee Sutapa, Roy Madhumita, Biswas Jaydip (2018). Oncogenesis and Telomerase Activity in Cancer: Rediscovering Cancer: From Mechanism to Therapy, Part I, Chapter 3; pg 21-58. ISBN No 978-1-77188-690-1 (Apple Academic Press). 5. Mukherjee Sutapa, Mukherjee Apurba, Biswas Souvick, Roy Madhumita (2018). Apoptosis: A Regulatory Mechanism in Cancer: Rediscovering Cancer: From Mechanism to Therapy, Part I, Chapter 3; pg 201-222. ISBN No 978-1-77188-690-1 (Apple Academic Press). 6. Ghosh Archismaan, Mukherjee Apurba, Mukherjee Sutapa, Roy Madhumita (2019) Role of Black Tea in prevention of Skin Carcinogenesis, LAP LAMBERT Academic Publishing. Research Support (details of) Sl No Title of the Project Funding Agency Status in the Project Duration 1. Modulation of therapeutic targets Aurora kinases A and B by phytochemicals in breast cancer cells. DST, New Delhi PI Dec’2015 – March’2019 2. Isothiocyanate: Role in enhancing platinum accumulation in cervical cancer. Ministry of Health & Family Welfare, Govt of India PI March’2017 – March’2020 3. A comparative study of the population chronically exposed to arsenic in two different demographic regions of Eastern India: identification of responsible genes and susceptible population DBT-Twinning, New Delhi, Govt of India Co-PI May’ 2017 – May’ 2020 3. Role of histone deacetylase inhibitors of natural origin towards sensitization of tumor cells via modulation of p53, p21 waf1/cip1 and c-myc. DST SERC Fast Track Fellowship PI August’2008 – August’2011 4. An investigation on the expression of various protein tyrosine kinases and their phosphorylated forms in different stages of the development of oral squamous cell carcinoma. (DBT-Twining), New Delhi, Govt of India Co-PI May, 2014 – May, 2017 Academic Activities: Registered PhD Students: 4 Post doctoral Students: 1 Short Term Trainee Students: 35
Primary Role Research;Science Administration;Science Communication
Leadership Projects Completed as Principal Investigator or Co-Principal Investigator at CNCI from 13.07.2009 onwards: 1. Isothiocyanate: Role in enhancing platinum accumulation in cervical cancer (PI). Ministry of Health & Family Welfare, Govt of India (March’2017 – March’2020). 2. A comparative study of the population chronically exposed to arsenic in two different demographic regions of Eastern India: identification of responsible genes and susceptible population (Co-PI). DBT-Twinning, Govt. of India (May’ 2017 – May’ 2020). 3. Modulation of therapeutic targets Aurora kinases A and B by phytochemicals in breast cancer cells (PI), DST, Govt. of India (Dec’2015 – March’2019) 4. An investigation on the expression of various protein tyrosine kinases and their phosphorylated forms in different stages of the development of oral squamous cell carcinoma (Co-PI). DBT-Twining, Govt. of India, (May, 2014 – May, 2017). 5. Role of histone deacetylase inhibitors of natural origin towards sensitization of tumor cells via modulation of p53, p21 waf1/cip1 and c-myc (PI). DST SERC Fast Track Fellowship, (August’2008 – August’2011).
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